Journal of Health Sciences and Medicine
Yazarlar: Çiğdem ÖZDİLEKCAN, Tarkan ÖZDEMİR, Ümüs Dilay ÇİMEN, Melike BAHÇECİTAPAR
Konular:Sağlık Bilimleri ve Hizmetleri
DOI:10.32322/jhsm.722178
Anahtar Kelimeler:Cancer,D-dimer,Cut-off,Pulmonary embolism
Özet: Aim: Cancer patients have increased risk of thrombosis. However, the use of D-dimer as a biomarker in malignancies, major surgery, infections and pregnancy was not recommended since D-dimer values were detected in high levels without PE. In this study, we aimed to evaluate the D-dimer values for the selected group of patients in the light of their clinical and demographic data and to reveal the utility of blood D-dimer measurements in cancer patients as a clinical decision rule. Also we aimed to define a new cut- off value for cancer patients who accurately diagnosed as pulmonary embolism. Material and Method: This single -center retrospective and cross-sectional study was based upon patients’ medical reports. The D-dimer values above 500 mcg/dl (>500 mcg/dl ) were considered as positive results. Results: One hundred twenty-eight patients (44 cancer patients (the case), 84 without cancer history (the control)) with accurate diagnosis of pulmonary embolism were included in the study. The mean blood level of D-dimer in the control group was 1729.3±2272.5 mcg/dl while the same parameters were calculated as 3326.9±3162.2 mcg/dl in the group with history of cancer indicating that the presence of malignancy caused a higher level of D-dimer levels. The most appropriate cut-off value in cancer patients was found as 1205 mcg /dl which had the sensitivity of 74%, specifity of 64%. This value corresponded to 2.41 times of the upper limits of the D-dimer value according to our laboratory results. Conclusion: For the diagnosis of PE the blood D-dimer values were absolutely a useful and a valuable parameter in cancer patients. We obtained a different cut-off value for D-Dimer in cancer patients which we think that will probably be a guidance for the future perspective of clinicians.