Journal of Health Sciences and Medicine
Yazarlar: Seyfullah KAN, Adnan KARAİBRAHİMOĞLU
Konular:Sağlık Bilimleri ve Hizmetleri
DOI:10.32322/jhsm.640710
Anahtar Kelimeler:Diabetic retinopathy,Subclinical atherosclerosis,Monocyte to HDL ratio
Özet: ABSTRACT Aim: Incidence of cardiovascular diseases is gradually increasing in patients with diabetic retinopathy (DR). MHR (Monocyte/HDL ratio), is a novel marker related with cardiovascular and cerebrovascular diseases. The aim of this study was to investigate the relationship between a subclinical atherosclerosis marker, carotid intima media thickness (CIMT), and MHR in diabetic retinopathy patients without an apparent cardiovascular disease. Material and Method: 106 diabetic patients without an apparent cardiovascular disease and 35 healthy controls matched for age, gender and body mass index (BMI) were included in this study. The patients were separeted into four groups which were proliferative diabetic retinopahy (PDR , n=30), nonproliferative diabetic retinopathy (NPDR, n=35), diabetic patients without retinopathy (n=41) and control group (n=35). Anthropometric, biochemical parameteres and CIMT were measured. Correlation and regression analysis were done to assess the relation between MHR and CIMT. Results: MHR was significantly different between groups and significantly higher in PDR group (p < .001). CIMT, a marker for atherosclerosis, significantly differed between groups (p < .001). CIMT levels were significantly higher in PDR while similar values were found in other than groups. In PDR group, a significant correlation was found between MHR and CIMT ( r=0.96; p < .001). According to binary logistic regression analysis, MHR had a significant effect on CIMT [ β=0.206, (%95 CI : 1.004-1.505), P=0.046 ]. Conclusion: This study showed that in patients with diabetic retinopathy, high levels of MHR which is a non-invasive, simple and inexpensive marker, might be useful for determination of subclinical cardiovascular risk. This study which is the first in literature that investigated the relation between MHR and CIMT in diabetic retinopathy might have a benefit on early detection of cardiac risk in diabetic patients without an apparent cardiovascular disease.