Turkish Journal of Veterinary and Animal Sciences

Turkish Journal of Veterinary and Animal Sciences

Serum pharmacokinetics and tissue concentrations of a newrecrystallized enrofloxacin hydrochloride-dihydrate in hamsters

Yazarlar: Alma CARRASCOSA, Alejan De La PEÃ'A, Lilia GUTIERREZ, Hector SUMANO

Cilt 39 , Sayı 6 , 2015 , Sayfalar 661 - 667

Konular:-

Anahtar Kelimeler:Enrofloxacin,Enro-C,Hamster,Pharmacokinetics/pharmacodynamics,Tissue concentrations,Staphylococcus aureus,Leptospira interrogans,Escherichia coli

Özet: Pharmacokinetics (PK), pharmacodynamics (PD), and PK/PD ratios of a new solvate of enrofloxacin (enrofloxacin hydrochloride-dihydrate; enro-C), were studied in hamsters. Enrofloxacin from Baytril1397904493 5% (enroR) served as the reference preparation. Two groups of 60 Syrian golden hamsters were intramuscularly injected individually with 10 mg/kg of enroR or with enro-C. Tissue and serum samples were obtained for 72 h; enrofloxacin concentrations were determined by HPLC with UV detection. Ninety percent minimum inhibitory concentrations (MIC90) were determined for strains of methicillin-resistant Staphylococcus aureus, Leptospira interrogans, and Escherichia coli. All PK variables were statistically different between groups (P < 0.01). CMAX of enrofloxacin for enro-C was 17.3 μg/mL and it was 2.6 μg/mL for enroR. AUC was considerably higher for enro-C (459.2 μg/mL h vs. 19.9 μg/mL h). There were no statistically significant differences in MIC90 values between enroR and enro-C. Tissue concentrations of enro-C in all cases were higher and remained above the MIC for longer periods than those of enroR. Relevant PK/PD ratios for enrofloxacin (AUC/MIC ? 125 and CMAX > MIC = 10-12) are consequently superior for enro-C. Given the outstanding PK/PD ratios of enro-C, this new moiety is proposed as a possible solution when high tissue concentrations of enrofloxacin are necessary.


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BibTex
KOPYALA
@article{2015, title={Serum pharmacokinetics and tissue concentrations of a newrecrystallized enrofloxacin hydrochloride-dihydrate in hamsters}, volume={39}, number={6}, publisher={Turkish Journal of Veterinary and Animal Sciences}, author={Alma CARRASCOSA,Alejandro De La PEÃ’A,Lilia GUTIERREZ,Hector SUMANO}, year={2015}, pages={661–667} }
APA
KOPYALA
Alma CARRASCOSA,Alejandro De La PEÃ’A,Lilia GUTIERREZ,Hector SUMANO. (2015). Serum pharmacokinetics and tissue concentrations of a newrecrystallized enrofloxacin hydrochloride-dihydrate in hamsters (Vol. 39, pp. 661–667). Vol. 39, pp. 661–667. Turkish Journal of Veterinary and Animal Sciences.
MLA
KOPYALA
Alma CARRASCOSA,Alejandro De La PEÃ’A,Lilia GUTIERREZ,Hector SUMANO. Serum Pharmacokinetics and Tissue Concentrations of a Newrecrystallized Enrofloxacin Hydrochloride-Dihydrate in Hamsters. no. 6, Turkish Journal of Veterinary and Animal Sciences, 2015, pp. 661–67.