Anatolian Journal of Emergency Medicine

Yazarlar: Can AKTAŞ, Gökçe AKGÜL KARADANA, Elif DEĞİRMENCİ, Yoldaş DEMİRTAŞ, Şevki Hakan EREN

Konular:-

Anahtar Kelimeler:Myocardial infarction,Biomarkers,Percutaneous Coronary Intervention,Mortality

Özet: Aim: To assess the early prognostic values of admission cardiac biomarkers (CKMB, hs-Troponin T, BNP) in patients with STEMI by determining the association of these markers with mortality, Gensini scores and LAD involvement prospectively. Materials and Method: The current study was performed through the six-month period on 70 STEMI patients admitted to ED who had chest pain for the first time in their lives and underwent to percutaneous coronary intervention (PCI). Admission first cardiac biomarker values measured within 6 hours, patient demographics and clinical characteristics (age, gender, PCI results, LAD involvement) and Gensini scores calculated in regards to PCI results were recorded. Association of each cardiac biomarker (CKMB, hs-Troponin T, BNP) with the presence of mortality and LAD involvement was calculated. Correlation between biomarker levels and gensini scores were sought with Spearman correlation coefficients test. Results: BNP (p=0.005) and hs-Troponin T (p=0.002) were associated with increased mortality. There was no association between mortality and the first admission value of cardiac biomarkers (BNP, CK-MB, hs-troponin T) with Gensini score (p>0.05). Higher BNP values indicated higher LAD (+) lesion probability (p<0.05) while no association between LAD(+) lesion and the other biomarkers (CKMB, hs- Troponin T) (p>0.05). Conclusions: Acute STEMI with high BNP and hs-Troponin T levels predict increased mortality and needs more serious treatment and close follow-up. Additionally, higher BNP levels suggest a potential LAD (+) lesion which is closely related with mortality. Admission BNP and hs-Troponin T values indicate early prognostic outcome in STEMI patients, however they don’t point out the severity of the lesions.

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