Eurasian Journal of Biological and Chemical Sciences
Yazarlar: İnci Selin DOĞAN, Bahittin KAHVECİ
Konular:Eczacılık, Kimya, Ortak Disiplinler
DOI:10.46239/ejbcs.731933
Anahtar Kelimeler:Ultrasonic radiation,Conventional synthesis,Iminoester,Schiff base
Özet: Today, the majority of the drugs used in the treatment of diseases are obtained by synthesis. A large proportion of the compounds have obtained heterocyclic structure. Therefore, synthesis of new heterocyclic compounds has always attracted and continues to attract scientist. It is known that compounds bearing triazole skeleton in the heterocyclic have an important place. The reactions of 4-amino-triazole compounds, especially with aromatic aldehydes, have been known for a long time and this reaction is carried out by conventional heating methods. However, the development of alternative heating methods to these conventional methods has also recently been studied. One of the most important of these is organic synthesis by microwave method and it is widely used. Another alternative method that has recently been used in organic synthesis is the realization of organic synthesis reactions with ultrasonic radiation. Ultrasound-assisted organic synthesis is an environmentally friendly, modern and economical method used to accelerate reactions. In this study, optimum conditions were determined for this reaction by using ultrasonic radiation method and the results were compared with the classical method. For this purpose, in the first step iminoester was synthesized by using Pinner method. The reaction of this iminoester with ethylcarbazate gave the corresponding hydrazone. Then the reaction of this obtained hydrazone derivative with hydrazine hydrate, the 4-amino-1,2,4-triazole derivative compound was synthesized. In the final reaction step, the interaction of this amino compound with 3-bromo-4-fluorobenzaldehyde was carried out by conventional and novel method (ultrasonic radiation) to obtain the targeted imine compound. The chemical structure of the new compound will be determined by spectroscopic methods such as 1H- and 13C-NMR and IR. The results compared in terms of reaction time, yield and purity between conventional and ultrasonic method. And we found that the ultrasonic radiation method is much more advantageous.