Eurasian Journal of Biological and Chemical Sciences

Yazarlar: Ayşe ÖZYUĞURAN-ARİFOĞLU, Melek EROL TAYGUN, Saye KÜÇÜKBAYRAK

Konular:Mühendislik, Kimya

Anahtar Kelimeler:Composite scaffold,Bioactive glass,Theraupatic ions

Özet: In this study, it was aimed to produce BG/polymer 3D composite scaffolds with relevant ions in order to develop multifunctional scaffolds by using salt template-particulate leaching technique. The porous scaffolds were successfully synthesized and it was observed that there was a good pore interconnectivity maintained in the scaffold microstructure. In vitro bioactivity of the composite scaffolds was confirmed by Scanning Electron Microscopy, X-ray diffraction and Fourier-Transform Infrared Spectroscopy measurements. Furthermore, the release of therapeutic ions were determined as a function of immersion time in SBF, while the Sr ion release is in the range of 1.27-4.81 ppm, the Cu ion releases are 0.67-1.42 ppm for Cu doped BG, 1.53-4.54 ppm for Sr doped BG- 1% Cu, and 3.08-7.59 ppm for Sr doped BG- 2% Cu, respectively. This result indicated that the scaffolds can deliver controlled doses of strontium and copper toward the SBF medium that is the determinant for bone tissue regeneration.

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