Sağlık Bilimlerinde İleri Araştırmalar Dergisi

Yazarlar: Ezgi ERSOY, Esra EROĞLU ÖZKAN

Konular:Eczacılık

DOI:10.26650/JARHS2019-616370

Anahtar Kelimeler:Hypericum,St. John’s Wort,Biological Activity

Özet: The Hypericum species that belong to the family Hypericaceae, especially the most common Hypericum perforatum, are presently one of the most consumed medicinal plants in the world. In recent years, the use of products containing H. perforatum has increased dramatically all over the world.1 There is evidence that H. perforatum has been used for its wound healing and antidepressant effects since ancient times and was even believed to be “sacred” and was a part of religious rituals in medieval Europe.2 H. perforatum is known as “sarı kantaron” in Turkish, whereas the most common name in other countries is “St. John’s Wort”. Numerous studies have been conducted on the chemical constituents and biological activities of the Hypericum species. The major active constituents are considered to be hyperforin which is a phloroglucinol derivative, and hypericin, a naphthodianthrone compound. Furthermore, other biologically active constituents, such as flavonoids, phenolic acids, tannins, volatile compounds and xanthones are also present in the plant extracts.3 Several pharmacological activities of the Hypericum species have been documented so far. The present study gives a summary of the most recent studies related to some important properties, including its antidepressant effect, wound-healing effect, anti-inflammatory effect, antioxidant effect, antimicrobial effect, effects on neurodegenerative disorders, cytotoxic effect, analgesic, and antinociceptive effect. 

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