Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni

Yazarlar: Zeyno NUHOĞLU, Abdurrahman AKSOY

Konular:Veteriner Hekimlik

DOI:10.38137/vetfarmatoksbulten.704983

Anahtar Kelimeler:Anticoagulant,Resistance,Resistance testing,Rodenticide

Özet: Resistance to anticoagulants may develop in rodent populations for 5-10 years as a result of intensive use of anticoagulant rodenticides. Resistance to anticoagulants have been first detected the UK in 1958. Monitoring the resistance status of rodent populations is a pivotal component of integrated risk management. Failure to get results even though the application is done correctly in rodent control is accepted as an indicator of rodenticide resistance. Failure to get results even though the application is done correctly in rodent control is accepted as an indicator of rodenticide resistance. Three types of resistance have been described against anticoagulant rodenticides based on pharmacokinetics, nutrition and pharmacodynamics. The methods of determining anticoagulant rodenticide resistance are constantly being renewed with the development of scientific methods. These methods are feeding testing, blood clotting response testing (BCRT), hepatic vitamin K epoxide reductase (VKOR) assessment, specific genotypes that are markers of resistance. When the resistance to anticoagulant rodenticides is detected in the population, it is essential to identify resistant individuals and to fight with a correct strategy to prevent the spread of resistance. In this review, resistance determination methods for anticoagulant rodenticides were investigated for a successful rodent control.

---