Anatolian Current Medical Journal

Yazarlar: Şenay DURMAZ CEYLAN, Şuuri Ahsen CEYLAN, Fatih EKER, Aşkın GÜNGÜNEŞ

Konular:Sağlık Bilimleri ve Hizmetleri

Anahtar Kelimeler:Morbid obesity,Thyroid function tests,Weight loss,Metabolic syndrome

Özet: Introduction and Aim: Although the changes in thyroid functions have been demonstrated in obese subjects, the effect of weight loss on thyroid functions is not clear in morbid obesity. The aim of this study is to investigate the effects of weight loss on thyroid functions, anthropometric measurements, basal metabolic rate and metabolic syndrome parameters in patients with morbid obesity. Material and Method: In our study, 107 patients who had lost weight in the first 6 months in accordance with the weight loss program applied for morbid obesity (BMI≥40 kg/m2) were evaluated retrospectively. Anthropometric measurements with bioelectrical impedance, waist circumference, blood pressures, free T3 (FT3), free T4 (FT4), TSH, thyroid ultrasound, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, Homeostatic Model Assessment Insulin Resistance (HOMA-IR), glucose and insulin levels were recorded from patient records in obesity department. Results: After weight loss, there were significant decrease in fat mass (p=0.001), fat percentage (p=001, basal metabolic rate (p=0.01), waist circumference (p=0.001), and BMI (p=0.001). however, there were no change in muscle mass, lean body mass and bone mass; there were a statistically significant increase in mean FT4 level (1.23±0.18 vs. 1.29±0.21 ng / dL, p=0.01), but no significant differences were found in mean TSH and FT3 levels. There was no significant difference in fasting plasma glucose after weight loss in patients with morbid obesity, whereas fasting plasma insulin levels (p=0.001) and HOMA-IR (p=0.004) decreased significantly. Total cholesterol (p=0.014) and HDL cholesterol (p=0.003) decreased, systolic blood pressure (p=0.0001) and diastolic blood pressure decreased significantly (p=0.001) Conclusions: According to our data, weight loss in patients with morbid obesity caused an increase in thyroid function only in FT4 levels, but this minimal increase of FT4 levels does not have clinical significance. Our patients have decreased blood pressure, total cholesterol, waist circumference, and insulin resistance, and improved metabolic syndrome parameters within the first 6 months, even if morbid obesity persisted after weight loss.

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