Turkish Journal of Internal Medicine

Yazarlar: Ahmet Bilgehan ŞAHİN, Fazıl Çağrı HUNUTLU, Nesrin UĞRAŞ, Macit GÜLTEN

Konular:Genel ve Dahili Tıp

DOI:10.46310/tjim.814732

Anahtar Kelimeler:Celiac disease,Hyperlipasemia,Macrolipasemia,Pancreatic hyperenzymemia

Özet: Lipase is a hydrolytic enzyme and commonly used for the diagnosis of pancreatitis with amylase. Except for pancreatitis, lipase is elevated in many clinical conditions such as hepatobiliary disorders, bowel diseases, malignancies, renal impairment. Celiac disease (CD) should be considered as one of the causes. In patients with CD, the frequency of pancreatic hyperenzymemia and possible pathophysiological mechanisms are not well studied. To date, several mechanisms explaining pancreatic hyperenzymemia in CD are reported. Malnutrition, disease bowel induced pancreatic dysfunction, autoimmune pancreatic inflammation, and macroenzymemia are the main ones. Herein, we report a patient with newly diagnosed CD, representing markedly elevated serum lipase level with normal amylase.

---