Turkish Journal of Internal Medicine

Yazarlar: Yasemin AYDOĞAN ÜNSAL, Özen ÖZ GÜL, Soner CANDER, Canan ERSOY, Oktay ÜNSAL, Ensar AYDEMİR, Erdinç ERTÜRK

Konular:Genel ve Dahili Tıp

DOI:10.46310/tjim.786828

Anahtar Kelimeler:Insulin autoimmune syndrome,Hyperinsulinemic hypoglycemic state,Corticosteroids

Özet: Insulin autoimmune syndrome (IAS) is a rare cause of hyperinsulinemic hypoglycemia characterized by antibodies to endogenous insulin without exposure to exogenous insulin. In this report, we presented a case of insulin autoimmune syndrome with a history of fasting hypoglycemia. After work up and exlusion of other causes such as insulinoma, hyperinsulinemic hypogylcemic state of the patient was considered to have been induced by etofenamate. Although IAS is generally self limiting and dietary management and withdrawal of trigger drug are enough to maintain euglycemia, in some cases corticosteroids, plasmapheresis, rituximab can be used for treatment. In our case, despite dietary management, hypoglycemia was severe and the patient’s life quality was adversely effected. After treatment with prednisolone, hypoglycemic episodes became less and less frequent. IAS should be considered as a differential diagnosis of hyperinsulinemic hypogylcemic states to avoid unnecessary interventions.

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