Eurasian Journal of Toxicology

Yazarlar: Sinem DOĞRUYOL, İlker AKBAŞ, Zeynep ÇAKIR

Konular:Acil Tıp

Anahtar Kelimeler:Carbonmonoxide,Intoxication,Lactate,Poisoning

Özet: Objective:  This report describes the epidemiology and analyses the clinic status, treatment, morbidity of carbonmonoxide intoxication cases in a university hospital. Furthermore, the results of blood tests of cases mentioned in this study were evaluated in detail. Materials and Methods: In this retrospective study, patients diagnosed with toxic effects of carbonmonoxide were evaluated between years 2014-2018. The data extracted from the patients’ files included seasonal variation, age, gender, underlying comorbidities, smoking and alcohol abuse history, vital parameters, clinical manifestations and source of poisoning, laboratory and imaging records, treatment and outcome. Results:  A total of 653 patients were included in the study. Admissions during the winter was found to be higher that other seasons with a significant difference (p < 0.001). The most frequent symptoms were headache (%62.3), nausea (%42.3), sudden loss of consciousness (%15.9) and dizziness (%12.1). Lactate levels were positively correlated with carboxyhemoglobin values (r= 0.257, p < 0.001) and troponin I levels (r=0.267, p<0.001). A blood lactate concentration >2 mmol/L was associated with %40 sensitivity and %75 specificity for predicting hyperbaric oxygen therapy requirement. Hyperbaric oxygen therapy group had a longer hospitalization period, which was statistically significant (mean difference -0.98; 95% CI = -1.38, -0.57) (p <0.001). Conclusion:  Emergency medicine clinics are fighting almost alone in carbonmonoxide poisoning cases. Now it is required to develop new perspectives in these cases. Lactate can be used safely in the management of patients as an option. 

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