Eurasian Journal of Toxicology

Yazarlar: Seda DAĞAR, Yunsur ÇEVİK

Konular:Toksikoloji

Anahtar Kelimeler:Extracorporeal treatment,Intoxication,Toxicology,Hemodialysis

Özet: Extracorporeal treatments (ECT) include a heterogeneous group of methods for the removal of endogenous or exogenous toxins from the body and/or for the temporary replacement of one of the vital organs.ECT methods may play a key role in preventing mortality and morbidity in appropriate intoxication cases that do not respond to conventional treatments. In general, toxins with low molecular weight, low endogenous clearance, low volume of distribution and low protein binding are suitable for removal by ECT methods. Currently, the most common ECT methods are intermittent hemodialysis, intermittent hemofiltration/hemodiafiltration, continuous renal replacement therapy, hemoperfusion, therapeutic plasma exchange, exchange transfusion, albumin dialysis and extracorporeal membrane oxygenation.ECT methods are invasive procedures that bring some risks of complications. Therefore, in all toxin exposures that may benefit from ECT, the application decision should be made by evaluating the benefit and risk ratio on a case-by-case basis. In determining the most appropriate ECT method for the patient, both the characteristics of the toxin exposed and also the medical history and clinical status of the patient should be taken into consideration.In the near future, presenting a wide range of data about ECT applications beyond the case presentations to the literature will help to determine the optimal use strategies of these methods.

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