Asian Pacific Journal of Health Sciences

Yazarlar: Santosh Kumar Verma, Rishikant Mishra, Mudita Mishra, N. Balakrishnan

Konular:-

DOI:10.21276/apjhs.2017.4.4.28

Anahtar Kelimeler:Carbon tetrachloride,Feronia elephantum,Hepatoprotective,LIV 52

Özet: In the present study, the hepatoprotective activity of aqueous and ethanol extracts of Feronia elephantum Correa. (Rutaceae) stem bark and root was evaluated against carbon tetrachloride (CCl4 )-induced hepatic damage in rats. The CCl4 (5 ml/kg)-intoxicated rats were enhanced the serum transaminase (serum glutamic oxaloacetic transaminase [SGOT] and serum glutamic pyruvic transaminase [SGPT]), alkaline phosphatase (ALP), total bilirubin (TB), total cholesterol (TC), while total protein (TP) level was reduced. Treatment with aqueous and ethanol extracts of stem bark and root of F. elephantum (50 and 100 mg/kg) has brought back the altered levels of biochemical markers of hepatic damage such as SGOT, SGPT, ALP, TB, TC, and TP to the near normal levels in the dose-dependent manner as well as histopathological examination was carried out to evaluate hepatoprotection. The results of this study strongly indicate that F. elephantum has a potent hepatoprotective action against CCl4 -induced hepatic damage in rats.

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