Asian Pacific Journal of Health Sciences

Yazarlar: Prabhjot Singh Bajwa, Jaya Sharma, Anurag Bhargava, Shailesh Sharma, Abhimanyu Rai Sharma, Binu Raina

Konular:-

DOI:10.21276/apjhs.2018.5.1.11

Anahtar Kelimeler:Ac,I,Ol,Asthma,Immediate release tablet,Sodium starch glycolate,Terbutaline sulfate

Özet: Aim: Present study was aimed at developing an immediate release tablets (IRT) of Terbutaline sulphate (TS) that can be used forquick relief from asthma attacks. Method: IRT’s were formulated using Ac-Di-Sol and Sodium starch glycolate as superdisintegrants. There concentrations were optimized using a 32 full-factorial design to produce tablets able to disintegrate within 30 s with minimum friability. Then the tablets were evaluated for physical evaluation and drug release studies. Results: The optimizedIRT formulation (OIRT1) showed a disintegration time of 31.67 ± 0.577 s and friability value of 0.58 ± 0.021 %. The accelerated stability studies showed no significant changes in physicochemical properties and release behaviour. Conclusions: It can be concluded from the study that the IRT of TS can be successfully formulated to get a fast release and these tablets can be used to get quick relief from asthma attacks.

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