Asian Pacific Journal of Health Sciences

Asian Pacific Journal of Health Sciences

Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives

Yazarlar: Omprakash Sharma, Pankaj Sharma, Birendra Shrivastava, Jitender Singh

Cilt 5 , Sayı 4 , 2018 , Sayfalar 54-60

Konular:-

DOI:10.21276/apjhs.2018.5.4.10

Anahtar Kelimeler:Azole derivative,P,Itro Benzoic Acid derivative,Antimicrobial activity

Özet: This study includes the Synthesis of Azoles Based p-nitro Benzoic Acid Derivative. The compounds were prepared by reaction of p-nitro Benzoic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4-thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff’s bases. All the Schiff’s bases thus obtained were reacted with Thioglycolic acid to yield the title compounds. Synthesized derivatives were characterized by IR, H1NMR and screened for their antibacterial (S. aureus, B. subtilis, E. coli, and P. aerugiosa) and antifungal activity (A. Niger and C. albicans).

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@article{2018, title={Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives}, volume={5}, number={54–60}, publisher={Asian Pacific Journal of Health Sciences}, author={Omprakash Sharma,Pankaj Sharma,Birendra Shrivastava,Jitender Singh}, year={2018} }
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Omprakash Sharma,Pankaj Sharma,Birendra Shrivastava,Jitender Singh. (2018). Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives (Vol. 5). Vol. 5. Asian Pacific Journal of Health Sciences.
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Omprakash Sharma,Pankaj Sharma,Birendra Shrivastava,Jitender Singh. Synthesis and Antimicrobial Evaluation of Azole Based (p-Nitro Benzoic Acid) Derivatives. no. 54–60, Asian Pacific Journal of Health Sciences, 2018.
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