Asian Pacific Journal of Health Sciences

Yazarlar: Abhimanyu, Anurag Bhargava, Prabhjot Singh Bajwa, Binu Raina, Pankaj sharma, Shailesh Sharma

Konular:-

DOI:10.21276/apjhs.2019.6.1.2

Anahtar Kelimeler:Chronothepary,Valsartan,Hypertension,Pulsatile capsule,32 Full factorial design

Özet: Aim of the present study was to formulate, evaluate and optimize the Pulsincap delivery system of valsartan used for treatment of hypertension, based on the chronotherapeutic approach. The prepared pulsincap system consist of immediate release tablet sealed inside formaldehyde treated insoluble capsule body by hydrogel plug composed of polymer HPMC K15M and guar gum. The formulation produced was targeted for the preparation of time controlling pulsatile formulation to delivery drug to site and time controlling for enhancing the bioavailability of drug, so preliminary batches were prepared to study the effect of concentration of HPMC K15M and guar gum on the lag time of the drug release. Optimization of hydrogel plug was carried out by employing 32 full factorial design using Design expert 7 Software.

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