ADMET & DMPK

Yazarlar: ["Andrei Bogdanov", "Olga Tsivileva", "Alexandra Voloshina", "Anna Lyubina", "Syumbelya Amerhanova", "Ekaterina Burtceva", "Sergey Bukharov", "Alexander Samorodov", "Valentin Pavlov"]

Konular:-

DOI:10.5599/admet.1179

Anahtar Kelimeler:Isatin,Hemostasis,Phytopathogens,Antibacterial and antifungal activities

Özet: A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR- and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo- and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time.

---