ADMET & DMPK

ADMET & DMPK

Electrochemistry of redox-active Mn porphyrin-based SOD mimic MnTnBuOE-2-PyP5+ - Study of Redox Species Involved in ROS/RNS Scavenging

Yazarlar: Tin Weitner, Ines Batinić-Haberle

Cilt 2 , Sayı 3 , 2014 , Sayfalar 185-190

Konular:-

DOI:10.5599/admet.2.3.123

Anahtar Kelimeler:Metalloporphyrins,Oxidative stress,Superoxide,Peroxynitrite,Cyclic voltammetry

Özet: Manganese ortho tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, is a third-generation redox-active compound currently undergoing preclinical exploration. This work is intended to complement the already extensive research of its chemical and biological properties by a simple electrochemical study. The thermodynamic parameters related to the Mn(IV) porphyrin species of MnTnBuOE-2-PyP5+ determined in this work support its observed reactivity as an efficient scavenger of peroxynitrite. The corresponding driving forces for the possible single-electron or two-electron reductions of ONOO- have been estimated as well.

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@article{2014, title={Electrochemistry of redox-active Mn porphyrin-based SOD mimic MnTnBuOE-2-PyP5+ - Study of Redox Species Involved in ROS/RNS Scavenging}, volume={2}, number={185–190}, publisher={ADMET & DMPK}, author={Tin Weitner, Ines Batinić-Haberle}, year={2014} }
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Tin Weitner, Ines Batinić-Haberle. (2014). Electrochemistry of redox-active Mn porphyrin-based SOD mimic MnTnBuOE-2-PyP5+ - Study of Redox Species Involved in ROS/RNS Scavenging (Vol. 2). Vol. 2. ADMET & DMPK.
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Tin Weitner, Ines Batinić-Haberle. Electrochemistry of Redox-Active Mn Porphyrin-Based SOD Mimic MnTnBuOE-2-PyP5+ - Study of Redox Species Involved in ROS/RNS Scavenging. no. 185–190, ADMET & DMPK, 2014.
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