ADMET & DMPK

ADMET & DMPK

Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers

Yazarlar: Aneta Cernikova, Radka Opatrilova, Pavel Bobal, Josef Jilek

Cilt 2 , Sayı 4 , 2014 , Sayfalar 248-253

Konular:-

DOI:10.5599/admet.2.4.155

Anahtar Kelimeler:(S)-Alaptide,(R)-alaptide,Rutin,Carboxymethylcellulose gel,Skin permeation modifiers

Özet: The investigation deals with the influence of permeation of rutin from carboxymethyl cellulose gel through full-thickness pig ear skin by (S)- and (R)-alaptide as potential excipients. Alaptide, 8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. By means of this rapid screening it was found out that the permeation of rutin through the skin increased linearly with time and was enhanced by both enantiomers of alaptide: approx. 1.2-fold by (R)-alaptide and approx. 1.5-fold by (S)-alaptide.

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@article{2014, title={Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers}, volume={2}, number={248–253}, publisher={ADMET & DMPK}, author={Aneta Cernikova, Radka Opatrilova, Pavel Bobal, Josef Jilek}, year={2014} }
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Aneta Cernikova, Radka Opatrilova, Pavel Bobal, Josef Jilek. (2014). Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers (Vol. 2). Vol. 2. ADMET & DMPK.
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Aneta Cernikova, Radka Opatrilova, Pavel Bobal, Josef Jilek. Rapid Screening of Permeation of Rutin through Skin Using Alaptide Enantiomers. no. 248–253, ADMET & DMPK, 2014.
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