ADMET & DMPK

ADMET & DMPK

Prediction of ADME-Tox properties and toxicological endpoints of triazole fungicides used for cereals protection

Yazarlar: Ionuț Mădălin Gridan, Alecu Aurel Ciorsac, Adriana Isvoran

Cilt 7 , Sayı 3 , 2019 , Sayfalar 161-173

Konular:-

DOI:10.5599/admet.668

Anahtar Kelimeler:Oral bioavailability,Endocrine disruption,Carcinogenicity,Mutagenicity,Cardiotoxicity

Özet: Within this study we have considered 9 triazole fungicides that are approved to be used in European Union for protecting cereals: cyproconazole, epoxiconazole, flutriafol, metconazole, paclobutrazole, tebuconazole, tetraconazole, triadimenol and triticonazole. We have summarized the few available data that support their effects on humans and used various computational tools to obtain a widely view concerning their possible harmful effects on humans. The results of our predictive study reflect that all triazole fungicides considered in this study reveal good oral bioavailability, are envisaged as being able to penetrate the blood brain barrier and to interact with P-glycoprotein and with hepatic cytochromes. The predictions concerning the toxicological endpoints for the investigated triazole fungicides reveal that they. reflect potential of skin sensitization, of blockage of the hERG K+ channels and of endocrine disruption, that they have not mutagenic potential and their carcinogenic potential is not clear. Epoxiconazole and triadimenol are predicted to have the highest potentials of producing numerous harmful effects on humans and their use should be avoided or limited.


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KAYNAK GÖSTER
BibTex
KOPYALA
@article{2019, title={Prediction of ADME-Tox properties and toxicological endpoints of triazole fungicides used for cereals protection}, volume={7}, number={161–173}, publisher={ADMET & DMPK}, author={Ionuț Mădălin Gridan, Alecu Aurel Ciorsac, Adriana Isvoran}, year={2019} }
APA
KOPYALA
Ionuț Mădălin Gridan, Alecu Aurel Ciorsac, Adriana Isvoran. (2019). Prediction of ADME-Tox properties and toxicological endpoints of triazole fungicides used for cereals protection (Vol. 7). Vol. 7. ADMET & DMPK.
MLA
KOPYALA
Ionuț Mădălin Gridan, Alecu Aurel Ciorsac, Adriana Isvoran. Prediction of ADME-Tox Properties and Toxicological Endpoints of Triazole Fungicides Used for Cereals Protection. no. 161–173, ADMET & DMPK, 2019.