Current Proceedings on Technology

Current Proceedings on Technology

Analysis for Different Binding Modes of 11β-HSD1 Inhibitors in the Human and Mouse Species by Developing Pharmacophore Models

Yazarlar: Nam Sook Kang, Joo Yun Lee, Kee Young Kim

Cilt 3 , Sayı - , 2013 , Sayfalar -

Konular:-

Anahtar Kelimeler:11β-HSD1,Inhibitor,Pharmacophore,Docking,Thiazolidine

Özet: There is a difference in the sequence homology between the human and mouse 11β-HSD1 enzymes. Many researchers have had difficulties in identifying the compounds that are equivalently active towards both human and mouse 11β-HSD1 enzymes. The aim of this study was to build docking-based pharmacophore models that can demonstrate the differences of the structural features in human and mouse 11β-HSD1 enzymes using in-house compounds-thiazolidine derivatives as potential 11β-HSD1 inhibitors. It was possible to obtain new insights into the structural relationship of a series of compounds with the human and mouse 11β-HSD1 enzymes. High correlation coefficients of 0.64 and 0.70 were respectively obtained when comparing the activity of the thiazolidine derivatives with the actual measurements in human and mouse species.

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@article{2013, title={Analysis for Different Binding Modes of 11β-HSD1 Inhibitors in the Human and Mouse Species by Developing Pharmacophore Models}, volume={3}, number={0}, publisher={Current Proceedings on Technology }, author={Nam Sook Kang, Joo Yun Lee, Kee Young Kim}, year={2013} }
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Nam Sook Kang, Joo Yun Lee, Kee Young Kim. (2013). Analysis for Different Binding Modes of 11β-HSD1 Inhibitors in the Human and Mouse Species by Developing Pharmacophore Models (Vol. 3). Vol. 3. Current Proceedings on Technology .
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Nam Sook Kang, Joo Yun Lee, Kee Young Kim. Analysis for Different Binding Modes of 11β-HSD1 Inhibitors in the Human and Mouse Species by Developing Pharmacophore Models. no. 0, Current Proceedings on Technology , 2013.
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