Current Proceedings on Technology

Yazarlar: Faruk SERİN, Metin ERTURKLER, Mehmet GUL, Birgül YIGITCAN

Konular:-

Anahtar Kelimeler:K-Means,CAD,Computer aided diagnosis,NAFLD,Analysis of histopathological images

Özet: Non-alcoholic fatty liver disease (NAFLD) is one of the common liver diseases. Diagnosing and investigating the effect of substances used in treating this disease are performed by experts who examine histopathological tissue sections under microscope. However, this approach is prone to errors and subjective depending on personal experience of the expert. The purpose of this study is: with the help of computer- aided diagnosis systems to investigate the effects of Melatonin and Resveratrol agents on histopathological liver tissue sections damaged by applying carbon tetrachloride (CCl4) composition. The proposed system aims to eliminate the tendency to subjectivity and error by providing information compiled by calculating the rate of fat vacuoles in the form of macrovesicular and microvesicular in hepatocytes and the number of hepatocytes quantitatively to an expert. As a result, an expert can perform objective and quantitative assessment in diagnosing, grading and evaluation of the effects of Melatonin and Resveratrol substances on damaged liver tissue.

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