Türk Tıp Öğrencileri Araştırma Dergisi

Yazarlar: Kevser EROL, Çiğdem ÇENGELLİ ÜNEL, Mahsum AYAZ, Enes YEŞİLTUNA, Ezgi DEMİR, Hamza DALÇINAR, Bengihan ÖZCAN

Konular:Sağlık Bilimleri ve Hizmetleri

Anahtar Kelimeler:Antinociceptive activity,Dipyrone

Özet: Dipyrone is an analgesic, antipyretic and antiinflammatory drug that has been used for treating postopertive, colic, cancer pain, and migraine. It has some adverse effects such as of bone morrow suppression, sodium and water retention, and gastroenteropathy. Hydrogen sulfide (H2S) is a active-radical gas. The precursors of H2S were reported to overcome some drug side-effects. H2S was also shown to have activity against several pain-related situations. Study aimed to evaluate the contribution of H2S on central and peripheral antinociceptive activity of dipyrone. Male six weeks old Sprague Dawley rats were divided into five groups (n=6): Control (Saline, ip); dipyrone (50 or 100 mg/kg i.p); NaHS (5mg/kg i.p); NaHS (5mg/kg) + dipyrone (50 mg/kg). Tail clip and hot plate tests were applied to the animals 30 minutes before and one hour after the drug injections. Five minutes after the injection of 60 mg/kg acetic acid (%0,6), stretching number was counted for ten minutes. The results were expressed as mean±SEM of latency, %MPE (maximal possible effect) and stretching number. One way and two way ANOVA tests were used for statistical analysis. P<0.05 was accepted as significant. Both doses of dipyrone did not have a significant activity on tail clip test, but 100 mg/kg dipyrone showed significant antinociceptive activity on hot plate and stretching tests. NaHS (5 mg/kg) was increased latency only on hot plate test. But the combination of NaHS with dipyrone has significant antinociceptive activity. It seems that H2S increased the antinociceptive activity of dipyrone both central and peripherally.

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