Experimental and Applied Medical Science

Yazarlar: Büşra ŞEN HALICIOĞLU, Hülya BİRİNCİ, Mehmet YÜNCÜ

Konular:Tıp

Anahtar Kelimeler:Curcumin,Liver,Cisplatin,Electron microscopy

Özet: The toxic effects that occur in many patients receiving chemotherapy seriously affect the liver. Cisplatin used in many types of cancer causes hepatotoxicity by increasing oxidative stress in the liver. Curcumin is a compound with many properties such as antioxidant, antifibrogenic and anticarcinogenic. Due to these healing effects of curcumin, it is recommended in many areas as an antioxidant. In this study, the effect of the antioxidant properties of curcumin on the liver of rats given cisplatin was investigated. For this purpose, 26 adult male Wistar Albino rats were divided into 4 groups. Control group rats were given DMSO for 6 days. Curcumin group rats were given i.p 200mg / kg curcumin for 6 days. In the Cisplatin + Curcumin group, 200 mg / kg curcumin i.p was given daily for 6 days and a single dose of 20 mg / kg cisplatin i.p was given on the 3rd day only. On the 7th day, after the animals were sacrificed, liver tissue was taken for light and electron microscopy analysis. As a result, it showed that cisplatin causes steatosis in hepatocytes, congestion in sinusoids and portal areas even when administered acutely. Cisplatin is thought to cause these effects by increasing oxidative stress in the liver. By means of the antioxidant effects of curcumin, it is possible to reduce these destructive effects.

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