Experimental and Applied Medical Science

Experimental and Applied Medical Science

Effect of Antihistamine Levocetirizine Dihydrochloride on Cytogenetic Markers

Yazarlar: Hüsniye KUTLU, İbrahim Halil KENGER, Rima ÇELİK MISIRLI, Lale DÖNBAK, Ahmet KAYRALDIZ

Cilt 1 , Sayı 1 , 2020 , Sayfalar 29 - 35

Konular:Tıp

Anahtar Kelimeler:Chromosome Aberration,Cytotoxicity,Genotoxicity,Micronucleus,Levocetirizine Dihydrochloride

Özet: Levocetirizine dihydrochloride is the active ingredient of Alerinit, a second-generation antihistamine, used in the treatment of allergic diseases. This study was carried out to determine the probable genotoxic and cytotoxic effects of levocetirizine using chromosomal abnormality (CA) and micronucleus (MN) tests in human peripheral lymphocytes. In this study, cell cultures were treated with 2, 4, 8 and 16 μg / ml concentrations determined by preliminary study of Levocetirizine during 24 and 48 hours. As a result of our study, we observed that Levocetirizine does not cause any significant change compared to control in CA / Cell rate, abnormal cell percentage and mitotic index values, MN frequency, binuclear micronucleus cell rate and nuclear division index values at within the all studied concentrations and treatment periods. According to this research; levocetirizine dihydrochloride has no genotoxic and cytotoxic effects.

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@article{2020, title={Effect of Antihistamine Levocetirizine Dihydrochloride on Cytogenetic Markers}, volume={1}, number={29–35}, publisher={Experimental and Applied Medical Science}, author={Hüsniye KUTLU,İbrahim Halil KENGER,Rima ÇELİK MISIRLI,Lale DÖNBAK,Ahmet KAYRALDIZ}, year={2020} }
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Hüsniye KUTLU,İbrahim Halil KENGER,Rima ÇELİK MISIRLI,Lale DÖNBAK,Ahmet KAYRALDIZ. (2020). Effect of Antihistamine Levocetirizine Dihydrochloride on Cytogenetic Markers (Vol. 1). Vol. 1. Experimental and Applied Medical Science.
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Hüsniye KUTLU,İbrahim Halil KENGER,Rima ÇELİK MISIRLI,Lale DÖNBAK,Ahmet KAYRALDIZ. Effect of Antihistamine Levocetirizine Dihydrochloride on Cytogenetic Markers. no. 29–35, Experimental and Applied Medical Science, 2020.
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