Experimental and Applied Medical Science

Yazarlar: Deniz YILDIZ PEHLİVAN, Gülçin DURDAĞI

Konular:Tıp

Anahtar Kelimeler:Doxorubicin,Thymoquinone

Özet: This study was conducted to investigate the effects of thymoquinone on biochemical parameter changes in cardiotoxicity caused by doxorubicin (DOX). 18 Wistar albino male rats were used in our study. The rats were divided into three groups as control, doxorubicin and doxorubicin + thymoquinone (DOX + TQ) group. The control group received one-time saline from the tail vein on the 5th day of the experiment. On the 5th day of the experiment, the DOX group received a single dose of 45 mg / kg DOX from the tail vein. The DOX + TQ group received 50 mg / kg thymoquinone by gavage for seven days and a single dose of 45 mg / kg DOX from the tail vein on the 5th day of the experiment. Rats were sacrificed under ketamine-xylazine anesthesia and total blood samples were taken and biochemical parameters were evaluated on the last day of the experiment. According to the biochemical data, in DOX group in while the creatine kinase myocardial band (CK-MB), interleukin-6 (IL-6), interleukin-18 (IL-18), Total Oxidant Status (TOS) and malondialdehyde (MDA) levels increased, the Total Antioxidant Status (TAS) decreased compared to the control group. Compared to the DOX group, while the value of CK-MB, IL-6, IL-18, TOS and MDA decreased, TAS increased in the DOX + TQ group. Results of our study shows that the deteriorative effects of doxorubicin on blood parameters can be corrected by thymoquinone.

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