Anatolian Journal of Biology

Anatolian Journal of Biology

Synthesis, Characterization and Antiviral Activities of Some Novel 4-Thiazolidinones Derived from Imidazo[2,1-b][1,3]thiazole-5-carbohydrazide Hydrazones

Yazarlar: Mine ISAOGLU, Nesrin CESUR

Cilt 1 , Sayı 1 , 2020 , Sayfalar 22 - 30

Konular:Biyoloji

Anahtar Kelimeler:Drug research,Carbonyl compounds,4-Thiazolidinones,Hydrazide-hydrazones,Antiviral activity

Özet: The present study describes the synthesis, characterization and antiviral activity evaluation of some novel 5-(nonsubstitue/methyl)-4-oxo-2-(substituted phenyl)-1,3-thiazolidine-4-one derivatives bearing an imidazo[2,1-b][1,3]thiazole-5-carboxamide moiety at N-3 position of the 4-thiazolidinone ring. The structures of the new 4-thiazolidinone compounds were confirmed by the data obtained from elemental analysis, IR, 1H-NMR, 13C-NMR (proton decoupled) and 13C-NMR (APT) spectra. The cytotoxicities and antiviral activities of 4-thiazolidinones were evaluated in-vitro against different types of DNA and RNA viruses in different cell cultures. Neither of the compounds had anti-influenza and anti-HIV activities, but 4c and 5d showed some degree of antiviral activity against the other tested virus types.

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@article{2020, title={Synthesis, Characterization and Antiviral Activities of Some Novel 4-Thiazolidinones Derived from Imidazo[2,1-b][1,3]thiazole-5-carbohydrazide Hydrazones}, volume={1}, number={22–30}, publisher={Anatolian Journal of Biology}, author={Mine ISAOGLU,Nesrin CESUR}, year={2020} }
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Mine ISAOGLU,Nesrin CESUR. (2020). Synthesis, Characterization and Antiviral Activities of Some Novel 4-Thiazolidinones Derived from Imidazo[2,1-b][1,3]thiazole-5-carbohydrazide Hydrazones (Vol. 1). Vol. 1. Anatolian Journal of Biology.
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Mine ISAOGLU,Nesrin CESUR. Synthesis, Characterization and Antiviral Activities of Some Novel 4-Thiazolidinones Derived from Imidazo[2,1-b][1,3]Thiazole-5-Carbohydrazide Hydrazones. no. 22–30, Anatolian Journal of Biology, 2020.
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