ADO Klinik Bilimler Dergisi

Yazarlar: Afra Nur NAZLI, Sibel ÇEBİ ATAK, Sedat ÇETİNER

Konular:Diş Hekimliği

Anahtar Kelimeler:Iv zolendronic acid,Mronj,Osteonecrosis,Pathologic fracture

Özet: Bisphosphonates are drug group frequently used in the treatment of the diseases which is characterized by osteoporosis and metastatic bone resorption. Bisphosphonate originated drugs decrease bone remodeling by suppressing osteoclast activity. They cause late side effects such as osteonecrosis in the jaws in long term or high dose use. Particularly in IV use, bone involvement rates are relatively higher than oral use. Bisphosphonate related osteonecrosis of the jaws can be occurred spontaneously or after cases such as tooth extraction which makes the bone open to external environment and causes mucosa integrity lost. In the following period, pathological fractures might be occurred in the BRONJ region. The treatment process can become complicated with the systemic conditions of the patients. In this article, the treatment of osteonecrosis in the mandible after tooth extraction and subsequent pathological fracture formation of the patient who uses IV zolendronic acid because of multiple myeloma are presented

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