The Journal of Neurobehavioral Sciences
Yazarlar: Karagöz Esra, Şılar Çisem, Yılmaz Özlem Özge, Polat Tolga, Aslan Beste Tacal, Baltacıoğlu Begüm Su, Dogan Canan Sercan, Kaman Tugba, Ulucan Korkut
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Özet: Genetic and environmental factors are important determinants of the athletic performance. Sports genetic determines certain the alleles for the identification of the genes that affect athletic performance. Comprehensive researches, including the biology of mental properties are accumulating due to the improvement of the information of molecular biology. Dopamine is an important neurotransmitter of the dopaminergic system that affects the athlete mentally and psychologically. In this study, our goal is to determine the genotype and allele distributions of the DRD2 rs180047 polymorphism in the cyclists. 19 cyclists and 52 sedentary individuals (controls) participated in our study. Genotyping was carried out by real time PCR (rt-PCR) after DNA was isolated from buccal epithelial cells. In our cohort, AG and GG genotypes were detected as 6 (32%) and 13 (68%), respectively. In the control group, the respective AA, AG and GG genotypes were detected as 9 (17%), 18 (35%) and 25 (48%). No statistically significant difference was detected in terms of genotype distribution between the two groups (p= 0,1107). When allelic distributions were examined, in athlete cohort. A and G allele numbers were counted as 6 (16%) and 32 (84%), respectively. In the control group, same alleles were count as 36 (35%) and 68 (65%). There was no significant difference in the terms of alleles in our study cohort (p=0,0295). In our cohort, GG genotype and the G allele of the DRD2 rs1800497 polymorphism were dominant. Recent studies showed the association of the A allele with addiction. Therefore we hypothesized the association of the related allele and sucess in cyclists. Although we were unable to find statistically significant difference, we suggest to analyse the same polymorphism in athletes with different sport branches to fulfill the role of the given polymorphism.