The Journal of Neurobehavioral Sciences

Yazarlar: Adeniyi A. Tijani , Ugbabe G. Eyineyi , Jemilat A. Ibrahim , Samuel E. Okhale

Konular:-

DOI:10.5455/JNBS.1443629662

Anahtar Kelimeler:-

Özet: Datura metel leaves and seeds are widely used in ethno-therapeutic management of Rheumatic pain, asthma and insomnia. Its use has been associated with adverse alteration in behavior which has triggered interest in its safety on the central nervous system. This study was therefore designed to evaluate acute neuro-toxicological effects of aqueous –methanol extracts of Datura metel in mice. Oral Acute toxicity studies of the leaf extract was carried out in mice. The effects of the extract (25-100 mg/kg body weight orally) on total locomotive activity, motor coordination and spatial memory in Y-maze were evaluated in mice. The effect of Datura metel extract (25-100 mg/kg) in the presence of either atropine (0.3 mg/kg b.w.) or naloxone (0.5 mg/kg b.w., i.p.) on total locomotive activity in an open field apparatus was carried out with the view of predicting its mechanism of action. The oral median lethal dose (LD50) was greater than 2000 mg/kg b.w. The extract produced significant decrease (p<0.05) in total locomotive activity of the treated mice in the open field apparatus. The extract significantly (p<0.05) shortened the time spent on the rota-rod by mice treated with the extract and reduced spontaneous alternation behavior. Datural metel leaves extract produced in mice neuro-toxicological effects characterized by sedation and hypokinesia, motor coordination impairment and disruption of short term memory.

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