The Journal of Neurobehavioral Sciences

Yazarlar: Akam Ali Saeed , Rebeen Saeed , Zana Mohammed , Sarbast Hamid

Konular:-

DOI:10.5455/JNBS.1443216992

Anahtar Kelimeler:-

Özet: Neuromyotonia is a neuromuscular hyperexitability disorder characterized by muscle stiffness caused by continuous muscle fiber activity. It is an immune mediated disorder with elevated antibody level against presynaptic, voltage gated potassium channels, either as isolation or as a paraneoplastic process. Symptoms usually include muscle twitching during rest (myokymia), cramps, peudomyotonia (delayed relaxation), increased sweating, and sometimes motor weakness. In this case report, we present a seventy two year old man who presented with pain in both thighs for one month. It gradually became worse to involve feet and chest. His brain CT scan showed features of brain atrophy. EMG showed fasciculation along neuromyotonic discharges with characteristic wave in frequency and amplitude typical of Isaacs syndrome. Potassium channel antibodies were very high. Diagnosis of Isaacs syndrome was made. He was followed up for two months with treatment by three day course of methyl prednisolone followed by oral steroid and methotrexate with much improvement. This is the first case of Isaacs syndrome in Kurdistan.

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