The Journal of Neurobehavioral Sciences

The Journal of Neurobehavioral Sciences

Effects of Estrogen on Kynurenine pathway and NF-kB in TNF-α Induced Neuroinflammation

Yazarlar: Halime Eda Yalçın , Batu Kaan Aksulu , Fatih Ozen , Belkis Atasever Arslan

Cilt 5 , Sayı 3 , 2018 , Sayfalar 137-139

Konular:-

DOI:10.5455/JNBS.1530277827

Anahtar Kelimeler:-

Özet: Neuroinflammation involves glia activation, releasing of inflammatory mediators such as cytokines and chemokines, and formation of reactive oxygen and nitrogen species. It plays a central role in many neurodegenerative diases processes such as Alzheimer’s disease, Parkinson’s disease, dementia. Estrogen deprivation, commonly associated with aging, loss of learning and memory skills in postmenopausal women and Alzheimer’s disease. In this study, we studied effects of 17-ßestradiol on kynunerine pathway and NK-kB gene expression in neuroinflammation. According to our results, estrogen increased expression of kynunerinase gene and decreased IDO-1 gene expression after TNF-alpha incubation in differentiated SH-SY5Y cells. However, it did not change NF-kB gene expression.

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@article{2018, title={Effects of Estrogen on Kynurenine pathway and NF-kB in TNF-α Induced Neuroinflammation}, volume={5}, number={137–139}, publisher={Nörodavranış Bilimleri Dergisi}, author={Halime Eda Yalçın , Batu Kaan Aksulu , Fatih Ozen , Belkis Atasever Arslan}, year={2018} }
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Halime Eda Yalçın , Batu Kaan Aksulu , Fatih Ozen , Belkis Atasever Arslan. (2018). Effects of Estrogen on Kynurenine pathway and NF-kB in TNF-α Induced Neuroinflammation (Vol. 5). Vol. 5. Nörodavranış Bilimleri Dergisi.
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Halime Eda Yalçın , Batu Kaan Aksulu , Fatih Ozen , Belkis Atasever Arslan. Effects of Estrogen on Kynurenine Pathway and NF-KB in TNF-α Induced Neuroinflammation. no. 137–139, Nörodavranış Bilimleri Dergisi, 2018.
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