The Journal of Neurobehavioral Sciences

Yazarlar: Rafi Hira , Rafiq Hamna , Khan Ruba , Ahmad Fahad , Anis Javaria , Farhan Muhammad

Konular:-

DOI:10.5455/JNBS.1558487053

Anahtar Kelimeler:-

Özet: Memory disorders could be caused due to occurrence of various neurological disorders including strokes, neurodegenerative diseases, trauma, anxiety or depressive disorders. Aluminium is a well-known neurotoxicant and is associated with several neurodegenerative diseases that caused memory deficits and CNS functional impairments related to memory and learning whereas chronic forced swim stress affects learning abilities and impaired various brain regions such as prefrontal cortex and hippocampus which are involved in memory and learning processes. 36 male Albino wistar rats were divided into three groups: a) water (p.o.) control, b) AlCl3 (100 mg/kg bodyweight) (i.p.) test I and c) forced swim stress (20 oC, 10 minutes) test II for 14 days. Behaviors were assessed in Light/Dark transition Box, Open Field Test, Novel Object Recognition Test (NOR), T Maze Test and Morris Water Maze Test. Body weight and food intake were observed weekly. Animals administered with AlCl3 and FSS revealed reduced body weight and food intake while decreased total numbers of square crossed with greater latency to move in open field test and reduced time spent and entries in bright area of light/dark box. Deficient spatial memory in Morris water maze and T maze test and reduced discrimination index along with decreased duration of interactions with novel object in NOR test were observed in learning and memory tests. Present study determines that AlCl3 and FSS treatment could induce memory and cognitive impairment that lead to behavioral deficits and various other psychopathologies.

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