Journal of Applied Biological Sciences

Yazarlar: Hatice GÜNEŞ, Müjgan OKTAY, Fulya ÇELEBİ, Bahar TÜL

Konular:-

Anahtar Kelimeler:Plant extracts,Anti-microbial activity,Anti-cancer activity,Cancer cell lines

Özet: Many phytochemicals from different plant species have potency in treatment and prevention of cancer. Currently, substantial research have being carried out in many laboratories the world over to discover new plant extracts with high anticancer and/or antimicrobial activities. In this study, seven different plant species Glaucium flavum, Euphorbia falcata, Conyza canadensis, Chenopodium botrys, Catalpa sp., Quercus coccifera, Crataegus monogyna from Mugla region were examined for their antimicrobial and anticancer capacities. Disc diffusion method was used to study antimicrobial potency of ethanol extracts against Gram-positive and Gram-negative bacteria. Anticancer activities of the plant extracts were tested against the six different cancer cell lines using the MTT assay. The fruit extract of Q. coccifera was found to be the most effective extract (13-15 mm 80µg/disc inhibition zone) against S. albus, M. luteus and S.aureus. In addition, C. canadensis exhibited antimicrobial activity only against E.coli and B. subtilis (10-14 mm 80µg/ml inhibition zone). Based on MTT assays, all of the plant extracts resulted in different degrees of anticancer activity on six different cancer cell lines. The most effective extracts were from C. botrys, G. flavum, Catalpa sp and Q. coccifera which caused more than threefold decrease in the cell proliferation of K562, PC-3 and MCF-7 cell lines compared to control. In conclusion, among the seven tested plant extracts, only Q. coccifera and C. canadensis showed antimicrobial capacity. On the other hand, 4 plant extracts have displayed high anticancer potency. Future studies related with cell death will elicit the mechanisms of anti-tumor activities of the plant extracts

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