Journal of Pharmaceutical Technology

Yazarlar: Gülşah GEDİK, Seda ALACA

Konular:Farmakoloji ve Eczacılık

DOI:10.37662/jpt.2020.2

Anahtar Kelimeler:Anti-Aging,Anti-Pollution,Collagen,CollagContraction,Eye Cream

Özet: This is a study of the brown algae-derived hydrolyzed algin as used in eye cream formulation. Alginic acid sodium is a gelling and non-toxic anionic polysaccharide, which is used to bone tissue engineering, preparation of alginate hydrogels, encapsulating, hydrating, protective, and de-polluting action. The skin of eye contour is thinner and less dense in support fibres than other parts of the face. Therefore, cutaneous sagging is frequently seen to appear around 40 years of age, very often aggravated by environmental factors such as pollution. The objective of the study was to evaluate the effect of anti-pollution & anti-aging eye cream on the collagen contraction. The outcomes of the characterization analysis indicate the development of successful cream formulation with optimum characteristics. No microbial growth was observed. The collagen lattices were prepared with human dermal fibroblasts, for evaluation of the effect of the cream on the collagen contraction. The lattices were treated or not (control) with the tested cream and then incubated at 37°C for 96 hours. The surface of lattices was measured by image analysis, and the lattices contraction was analyzed at 16, 24, 40, 48, 64, 72, 88, and 96 hours (the measure of lattices area). The treatment with eye cream at 0.5% decreases the surface of the lattice compared to the control (no treatment). According to the results obtained under the conditions of the test, the eye cream tends to increase the collagen contraction and a significative decrease of the lattice surface by 6.68% compared to the control at 16 hours.

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