Journal of Pharmaceutical Technology

Yazarlar: Kadir AYKAÇ, Evrim YENİLMEZ, Müzeyyen DEMİREL, Ebru BAŞARAN

Konular:Eczacılık, Farmakoloji ve Eczacılık

Anahtar Kelimeler:Posaconazole,Chitosan,Ocular Inserts,Ocular Bioavailability,In-Vitro Release

Özet: Corneal and conjunctival infections are common ocular diseases, however sometimes, lead for blindness when neglected. Despite most of the ocular drug delivery systems are in eye drop form, they suffer from poor retention on the ocular surface and low ocular bioavailability leading to unsatisfactory results even with repeated treatment. Therefore there is a need for more effective drug delivery systems for ocular application. The present study was carried out to demonstrate that ocular inserts effectively delivers significant concentration of drug with topical administration for treatment of fungal infections with the help of extended residence time on the ocular suface. Chitosan based inserts were prepared by freeze drying method. The prepared inserts were evaluated for various parameters. Layered structures were revealed with scanning electron microscopy (SEM) analyses. Thermal and structural behaviours were analyzed by differential scanning calorimetry (DSC) and fourier-transform infrared spectroscopy (FT-IR) with nuclear magnetic resonance (1H-NMR) analyses respectively. Drug contents were evaluated by a validated HPLC method. In vitro release studies were also performed in simulated tear fluid (STF) at 34±1°C during 48 hours. Analyses results revealed that chitosan based ocular inserts were suitable systems for Posaconazole delivery for the treatment of severe ocular fungal infections.

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