International Journal of Health and Clinical Research
Yazarlar: Shikha Rawat, Sudeep Kumar, Manisha Arora, Shahid Iqbal, Jyoti Batra, Shivani Sharma, Sumesh Prasad Sah
Konular:-
Anahtar Kelimeler:Non,DL Cholesterol,Atherogenic Coefficient,Cardiac Risk Ratio,Dyslipidemia.
Özet: Introduction: Diabetic dyslipidemia is regarded as risk factor for development of cardiovascular disease and it is the primary cause of morbidity and mortality in diabetes. LDL- cholesterol is primarily used as the marker of CVD risk while other markers like lipid ratios, AIP and atherogenic coefficient are the better markers for the prediction of CVD. Objective: The present study was aimed to evaluate the non-HDL cholesterol, AIP and other cardiac indices as CVD risk in diabetic patients. Material & Methods: This cross-sectional study was carried out in the Department of Biochemistry and Department of Medicine Muzaffarnagar Medical College, Muzaffarnagar. Total 240 patients were enrolled for this study, out of which 120 were diabetic and 120 were normal healthy control of both the sexes. Anthropometric parameters like age, weight, height, blood pressure and the biochemical parameters including fasting blood sugar, lipid parameters, cardiac risk ratio, atherogenic index of plasma, atherogenic coefficient and non-HDL cholesterol were measured. For statistical analysis SPSS version 16 was used and for significance, p-value less than 0.05 was considered. Results: In this study, the fasting blood glucose, HbA1c, Total cholesterol, triglycerides, LDL-cholesterol were found to be increased significantly and HDL- cholesterol was found to be decreased significantly in Diabetic patients as compared to normal healthy control. The cardiac indices like, Cardiac Risk ratio (CRR), atherogenic Index of plasma (AIP), atherogenic coefficient (AC) and non-HDL cholesterol were also found to be increased significantly in diabetic patients as compared to normal healthy individuals. Conclusion: The present study concluded that the lipid ratios are more convenient clinically and they can be useful in assessing the cardiovascular complications in diabetic patients instead of lipid profile alone.