International Journal of Health and Clinical Research

Yazarlar: Shachi Dixit, Shikha Jain

Konular:-

Anahtar Kelimeler:Thrombocytopenia,Platelet indices,Neonatal sepsis,Diagnosis.

Özet: Diagnosis of neonatal septicemia may be difficult as the early signs of sepsis may be subtle and different at different gestational ages. Platelet indices are helpful in the diagnosis as well as follow-up of sepsis including assessing the response of antimicrobial treatment if interpreted cautiously. However, these platelet indices are not appropriate always. The important platelet indices available for clinical utility include mean platelet volume (MPV), platelet distribution width and plateletcrit that are related to morphology and proliferation kinetics of platelets. Thrombocytopenia is a common hematological abnormality in neonates with sepsis. Abnormal MPV can aid diagnosing the cause of thrombocytopenia. Low MPV associated with thrombocytopenia has been found to result in clinical bleeding. Until recently, the mechanism of neonatal thrombocytopenias are unclear. As a result, classifications based on mechanism have proved of little practical help to neonatal paediatricians because of overemphasis of rare conditions of known mechanism. The studies addressing the importance of these platelet indices and thrombocytopenia may provide insights for the early diagnosis of neonatal sepsis and therapy that would reduce the mortality rate. This review presents the details about the thrombocytopenia and its mechanism as a diagnostic measure for neonatal sepsis.

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