International Journal of Health and Clinical Research

Yazarlar: Penugonda Anveetha, Vamsi Krishna Chittimoju, Sujatha Pasula

Konular:-

Anahtar Kelimeler:Oxidative stress,Antioxidants,COPD,Superoxide dismutase,Vitamin C,Malondialdehyde.

Özet: Background: High morbidity and mortality are associated with chronic obstructive pulmonary disease (COPD). COPD is generally correlated with a history of consuming tobacco. The tissue damage seen in COPD is due to free radicals in the smoke. Several studies have shown a significant correlation between oxidative stress and COPD. Antioxidant reductions also contribute to oxidative stress, as antioxidants not only protect against the direct harmful effects of oxidants but also modify inflammatory events which play an important role in COPD pathogenesis.Methods: The total number of subjects studied was 100, consisting of 50 safe controls and 50 cases of COPD. Out of 50 cases of COPD, 25 were patients with chronic bronchitis and 25 were patients with emphysema. Malondialdehyde (MDA) levels of oxidants were measured, and superoxide dismutase (SOD) and vitamin C levels of antioxidants were measured. Cases and controls were tested for superoxide dismutase, vitamin C, and malondialdehyde levels.Results: Serum superoxide dimutase and vitamin C levels were significantly reduced and serum MDA was significantly increased as compared to controls in COPD cases. Compared to chronic bronchitis patients, the abnormality was more significantly seen in emphysema patients.Conclusion: The present study suggests that the increased MDA levels in COPD patients are due to increased lipid peroxidation mediated by toxic free radicals and decreased levels of serum superoxide dismutase and vitamin C as a result of increased oxidative stress. Further studies, to evaluate the molecular mechanisms by which antioxidants modulate their protective role and also to identify new antioxidant molecules which may well prove to be better preventive factors or additional protective factors, should be done.

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