International Journal of Health and Clinical Research

Yazarlar: Akanksha Agrawal, Puneet Jain, Rajrani Sharma

Konular:-

Anahtar Kelimeler:Cesarean section,Misoprostol,Intraoperative and postoperative blood loss,APGAR score.

Özet: Aim and Objectives: To evaluate the effect of preoperatively administered 600 microgram misoprostol via rectal route on cesarean section related intraoperative and postoperative blood loss at 24 hours and its effect on APGAR score at 1 min and 5 min in cesarean section.Materials and Methods: A randomized controlled trial was conducted among 200 women scheduled for cesarean delivery who did not have any risk factor for postpartum hemorrhage. The study group (n= 100) received 600 microgram of misoprostol. The control group(n=100) received placebo. Misoprostol was administered rectally just after spinal anaesthesia. Primary outcome measured were amount of intraoperative blood loss, blood loss at 24 hour postoperative and difference between APGAR scores in both groups at 1 min and 5 min.Results: The mean intra operative and postoperative blood loss at 24 hour was significantly lower in the study group than the control group (440 ±252 ml versus 635±360 ml: p=0.03)(174 ±78 ml versus 310±152 ml; p=0.001). Admission to the neonatal intensive care unit and APGAR scores at 1 and 5 min were comparable between 2 groups. {7.4±1.4 and 7.9 ±1.4 at 1 min (p=0.28) and 9.0±0.7 and 8.8±0.6 at 5 min (p=0.24)}. The incidence of shivering was higher in study group.Conclusion: Preoperative treatment with rectal administration of 600 microgram misoprostol significantly reduces blood loss related to cesarean delivery. However, occurrence of transient side effect such as shivering was noted more frequently with the use of misoprostol.

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