International Journal of Health and Clinical Research

Yazarlar: Devleena Bhowmick, Shubham Kumar, Saba Nasreen, Raunaque Saba, Haider Iqbal, Love Kumar Bhatia

Konular:-

Anahtar Kelimeler:Keywords: OSMF,Lycopene,Hyaluronidase,Antioxidant

Özet: Introduction: OSMF is a common potentially malignant disorder found in India caused by chewing gutkha with tobacco. Many studies have proven the beneficial effect of antioxidants in the management of osmf.Aim: The aim of the present study is to compare the efficacy of antioxidant Lycopene alone and in combination with intralesional Hyaluronidase injection in the treatment of OSMF patients.Material and Method: 50 diagnosed OSMF patients (Stage-2) were included in the study and were divided randomly into two groups. Group-A patients received 8 mg capsule of lycopene daily in two equally divided dose while Group-B patients received 8 mg capsule of lycopene daily in two equally divided dose in combination with intralesional injection of hyaluronidase 1500 IU twice weekly for 3 month. The clinical parameters (inter-incisal mouth opening & VAS for burning) were evaluated at baseline & at the completion of treatment on 90th day.Results: By the completion of study, inter-icisal mouth opening increased significantly (p<0.05) from 25.20 ± 3.01 mm to 29.36 ± 3.17 mm& 24.58 ± 3.90 mm to 32.41 ± 3.22 mm for Group-A & Group-B patients respectively. Changes in VAS for burning sensation decreased significantly (p<0.05) from 7.16 ± 0.96 to 0.88 ± 0.72 &6.47 ± 1.10 to0.20 ± 0.12 for Group-A & Group-B patients respectively. Also, Group-B patients witnessed statistically significant changes in clinical parameters at 90th day compared to Group-A patients. Conclusion: Lycopene in combination with intralesional hyaluronidase is more effective in treating the patients with OSMF than lycopene alone.

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