International Journal of Health and Clinical Research
Yazarlar: Maneesh Jain, Devpriya Shukla, Amit Jain
Konular:-
Anahtar Kelimeler:Poisoning,Rganophosphorus compounds,Suicide,Serum cholinesterase
Özet: Background: India is predominantly a country of farming. Use of organophosphorus pesticide is widespread in India. Acute organophosphorus poisoning(AOP) is highly prevalent in Indian population causing huge morbidity and mortality.Aim and objective: To study the clinical profile and manifestation of patients with AOP.Materials and methods: Thirty-one patients with AOP were studied at Emergency Department of Sri Aurobindo Medical college and PG Institute, Indore, from December 2017 to May 2019. All the relevant medical, personal, and surgical history was obtained. All patients were subjected to complete blood count. serum cholinesterase levels, blood urea and serum creatinine, serum electrolytes, SGOT and SGPT, chest X-ray and ECG.Results: Majority of the patients with AOP were males (74.2%) with mean age of 38.42±16.31 years. Mean duration of reporting to hospital after poisoning was 73.23±56.96 minutes.Vomiting (96.8%) followed by salivation (90.3%), sweating (74.2%), respiratory depression (51.6%) and muscle weakness/fasciculations (35.5%), convulsions (22.6%) and diarrohea (16.1%) were the most common symptoms. Pupil size of majority patients (45.2%) was more than 2 millimeter. According to peradeniya organophosphorus (POP) scale, majority were mild cases (54.8%). Majority had serum Cholinesterase Level (KU/L) <1 (38.7% followed by 32.3% cases who had level >4.62.Response to pain in 11 cases (35.5) was found to be the most common level of consciousness. Majority had total hospital stay of 0-7 days (67.7%) and ICU duration of 0-7 days (90.3%). Total duration of ventilator support in 41.9% was found to be more than one week. Death was reported in 25.8%patients with AOP.Conclusion: AOP was common in male belong to working age group. A delay in presentation to hospital was reported. Vomiting, salivation, sweating, respiratory depression, muscle weakness/fasciculations, convulsions and diarrohea were the most common symptoms. Majority were mild cases as per POP scale with serum Cholinesterase Level (KU/L) <1. However, mortality is hight among the patients presented with AOP.