International Journal of Health and Clinical Research

Yazarlar: Sanjay Somashekar, Hemareddy Betageri, Vinaya KumarJogondra, Shrikant Hiremath, Harsha Hanji

Konular:-

Anahtar Kelimeler:Chronic obstructive pulmonary disease,C reactive protein,Bacterial exacerbation,Non,Bacterial exacerbation

Özet: Background:Chronic obstructive pulmonary disease (COPD) exacerbation is a cause of high mortality in COPD patients. C reactive protein (CRP) role in predicting exacerbation has been studied before, but it’s value in Predicting etiology is not well established. In this study the role of CRP to determine the presence of bacterial exacerbations in Indian population was studied which could guide us in early initiation of therapy in these cases.Methods:In this study CRP levels were measured from patient’s serum using nephelometric method. Sputum samples were obtained from COPD Acute exacerbations (AE) patients and evaluated microscopically and subjected to culture. 60 patients with Bacterial exacerbation were compared with 33 patients of Non-Bacterial exacerbation and the relationship between CRP and Bacterial exacerbation was assessed. Results:Using Mann-Whitney U-test, high CRP median values were seen in Bacterial COPD AE as compared to Non-Bacterial COPD AE. The ideal cut-off point in our study for distinguishing Bacterial COPD AE with Non-Bacterial COPD AE was 7.62 mg/l calculated using Youden criteria (sensitivity: 96.67%; specificity:39.39%; PPV:74.36%; NPV:86.67%, AUC:0.64(95% CI: [0.52,0.77])Conclusion:In patients exhibiting symptoms of COPD AE an elevated serum CRP level >7.62mg/l indicates Bacterial exacerbation which might be useful in early initiation of antibiotic therapy in these cases.Abbreviations: COPD: Chronic obstructive pulmonary disease, CRP: C reactive protein, AE: Acute exacerbations

---