International Journal of Health and Clinical Research

Yazarlar: Krishna Kumar Tripathi, Yamini Jamod, Payaswinee Sharma, R.P.Kaushal, Chandrakant

Konular:-

Anahtar Kelimeler:Transfusion,Ranexamic acid

Özet: Objective: We conducted this clinical study to compare standard dose of Tranexamic acid with moderately high dose of Tranexamic acid in controlling bleeding and reducing transfusion requirement in primary elective mitral valve replacement surgery with cardiopulmonary bypass. Methods:A total of 60 American Society of Anesthesiology (ASA) grade II and III patients undergoing elective mitral valve replacement surgery.Group I received low dose Tranexamic acid 12.5 mg/kg iv loading dose over 20 mins after anaesthesia induction followed by iv infusion 4mg/kg/hr until chest closure.Group II received moderately high dose Tranexamic acid 25mg/kg iv loading dose over 20 mins after anaesthesia induction followed by iv infusion 8mg/kg/hr until chest closure.Results: The group received moderately high dose of tranexamic acid has less bleeding compared to group which received standared dose of tranexamic acid. The groups were similar with respect to post op ventilatorysupport,blood transfusion requirement and post op nausea and vomiting.Conclusion: The current study establishes moderately high dose of tranexamic acid were more effective to prevent intra- op and post- op bleeding in patients undergoing mitral valve replacement surgery.

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