International Journal of Health and Clinical Research
Yazarlar: T. Aruna Kumari, G. Anil Kumar, A. Jyotsna, R.Kathyaini
Konular:-
Anahtar Kelimeler:HbA1c,Serum Ferritin,Serum Nitric Oxide,Serum Uric acid andType 2 Diabetes Mellitus.
Özet: Background: Diabetes mellitus (DM) is a commonest metabolic disorder affecting the people all over the world. There is growing evidence that increased iron stores in the body leads to developmentof glucose intolerance, type 2 DM and insulin resistance syndrome. Several studies have shown that development of endothelial dysfunction is the major cause for vascular complications in type 2 DM subjects and altered bioavailability of serum nitric oxide is found be the underlying cause for endothelial dysfunction in diabetic subjects. Objectives: To estimate fasting plasma glucose, serum ferritin, serum nitric oxide, HbA1cand uric acid levels in type 2 DM subjects and compare the values with healthy controls and to do the correlation analysis between these biochemical parameters in type 2 DM subjects. Materials and methods: A case control study is conducted in a total of 56 diagnosed type 2 DM subjects and 31 healthy controls. Fasting plasma glucose, serum ferritin,serum nitric oxide, HbA1c, and serum uric acid are estimated in all cases and control group. Results: Intergroup comparison of biochemical parameters was done by unpaired “t” testand correlation between parameters by Pearson coefficient analysis. In DM subjects, mean values of serum ferritin, serum nitric oxide, HbA1c, and serum uric acid were found to be significantly increased (p<0.001) when compared to controls. Moreover, Serum ferritin has shown significant positive correlation with HbA1cand serum nitric oxide in type 2 DM patients with „p‟ value of <0.05. Conclusion: The present study suggests that oxidative stress is one of the major factors in the pathogenesis of type 2 DM. There is a need to prevent iron over load in type 2 DM subjects which may occur through many ways. Decreasing iron stores may reduce the oxidative stress, improve the vascularendothelial dysfunction andalso improves insulin sensitivity in type 2 DM subjects.