International Journal of Health and Clinical Research

Yazarlar: DoffouAdjeka Stanislas, Assi Constant, Illa Hamidine, Bangoura Aboubacar Demba, Kouame Dimitri, Allah Kouadio Emile, Nigue Luc, Anzouan Kissi Henriette, Mahassadi Alassan Kouame, Yao Bathaix Fulgence, Attia Koffi Alain, Lohoues Kouacou Marie Jeanne

Konular:-

Anahtar Kelimeler:Helicobacter pylori quadruple therapy eradication endemic co u ntry real life

Özet: Background : The effectiveness of rate of eradication Helicobacter pylori is unknown in Côte d'Ivoire in daily practice. Objectives : The aim of our study was to assess the effectiveness of 4 quadruple therapies Materials and Methods : This was a retrospective multi center study carried out in Abidjan. The medical records of naive patients over 18 years old treated with quadruple therapy [sequential (Q s), concomitant 10 (Qc10) or 14 days (Qc14) or bismuth based therapy (Qb)]confirmed histologically on gastric biopsies were included. All had a histologic al check for the eradication of H pylori at least 4 weeks after the en d of treatment. The quadruple th erapy eradication rate has been determined. Results : One hundred and seventy files were included. The overall eradication rate was 60.6% [53.3% 67.9% 95% CI]. It was 55.6% for Qs (30/54, [42.3% 68.9% 95% CI]), 80% for Qc10 (8/10, [55.2% 100% 95% CI ]]), 58.3% for Qc14 (49/84, [47,756%, 68,844% 95% CI]) and 72.7% for Qb (16/22, [54,084%, 91,316% 95% CI]). The patients of the 4 protocols were comparable for age (p = 0.054); gender (p = 0.157); reason p = 0.173) and endoscopy result (p = 0.244); intensit y of antral (p = 0.542) and fundic (p = 0.744) H pylori infection in histology; frequency of side effects (p = 0.131) and adherence to therapy (p = 0.564). Conclusion s : T he eradication rate of H pylori in daily practice was not optimal regardless of the qua druple therapy regimen used. A study of the resistance of H pylori to different antibiotics is necessary.

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