International Journal of Health and Clinical Research

Yazarlar: Poojashri M Sharma, Rajesh P Karyakarte, Nitin A Ambhore, Rupali S Mantri

Konular:-

Anahtar Kelimeler:Nosocomial infections,AMR,ESBL

Özet: Background: Infections play vital role in determining the outcome as well as cost and duration of the hospital stay for patients admitted in Intensive Care Unit (ICU) setup. One of the major problems Worldwide is the rise in Antibiotic-Resistant Strains of bacteria, mainly in hospitals. Infections frequently encountered with drug resistant organisms include those with Methicillin Resistance Staphylococcus aureus (MRSA), Extended-Spectrum β-Lactamase (ESBL), and Metallo β-Lactamase (MBL) producing organisms.Extended-spectrum β-lactamase (ESBL) producing strains of Enterobacteriaceae have emerged as a challenge in hospitalized patients as well as in the community. Objectives: 1. To isolate and identify bacterial pathogens in Adult Intensive Care Unit (ICU). 2. To study antimicrobial susceptibility patterns of gram negative organisms isolated from samples in Adult ICU. 3. To detect presence of Extended Spectrum β Lactamases in all Enterobacteriaceae isolates. Material and methods: Depending on sites of infections various samples were collected and processed for bacterial identification and antibiotic susceptibility as per the standard guidelines. Results: Of the total 130 bacterial isolates Pseudomonas aeruginosa was the predominant isolate 32 (24.61%) followed by E. coli 27 (20%), K. pneumonia and S. aureus, 18.46% each. Gram negative bacilli were found to be commonest cause of ICU infection. ESBL production was found in 35.71% of Enterobacteriaceae isolates. Conclusion: ESBL producing organisms pose a major problem for clinical therapeutics. Judicious use of antimicrobials, strict adherence to the antibiotic policy and infection control practices, implementation and practice of antibiotic stewardship programme are measures to reduce infections in ICU.

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