International Journal of Health and Clinical Research

Yazarlar: Priyank Goyal, Dinesh Chandra Punera, Ram Gopal Nautiyal, Bhavana Srivastava, Rajesh Kumar Singh

Konular:-

Anahtar Kelimeler:Incidence,Adverse drug reactions (ADRs),Multidrug resistant pulmonary tuberculosis (MDR,TB).

Özet: Background: Treatment of multidrug resistant pulmonary tuberculosis (MDR-PTB) is challenging because of multiple anti-TB drugs, long treatment duration and various adverse drug reactions (ADRs). The aim of this study was to find the incidence of ADRs related to various anti-TB drugs. Methods: This was a prospective observational study done from 1st January 2019 to 30th June 2020, in the Department of Respiratory Medicine at Government Medical College, Haldwani, Uttarakhand. Results: A total of 163 MDR-PTB patients were reviewed, of which 136 (83.44%) patients experienced >1 ADRs, during intensive phase of treatment. Total 398 ADR episodes were observed, maximum ADRs (134, 33.7%) were related to Gastrointestinal system. Incidence of ADRs was more (96.97%) in 46-60 yrs. of age group, in patients living in rural area (82 of 92, 89%), in married patients (88.07%), in smokers (91.4%), in alcoholics (90.6%), in patients having co-morbidities and in patients who had anemia (88.24%). The most common ADR was joint pain in 36 (26.5%) of 136 patients. Conclusion: Strict follow-up with laboratory investigations, providing assurance and exercise plan to the patients is crucial. Healthcare providers should be trained regarding identification and management of ADRs.

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