International Journal of Health and Clinical Research
Yazarlar: Yerraguntla Shashidhar, Golla Vahini
Konular:-
Anahtar Kelimeler:CRP,Myocardial Infarction,Diabetes Mellitus
Özet: Background: In this study we wanted to determine the CRP level at the time of admission as a strong predictor of hospital mortality and morbidity in patients with Diabetes mellitus as well as in patients without Diabetes mellitus who had acute myocardial infarction. Methods: This is a longitudinal study, conducted among patients of acute myocardial infarction admitted in ICU in Gandhi Medical College, from January 2021 to December 2021. Foe each study patient, a detailed history was taken, he/she was examined in detail, relevant investigations like ECG changes, lipid profile, CPKMB enzyme levels, blood glucose levels (FBS/PPBS) and C-reactive protein were done, the patient was followed till discharge and all complications like arrhythmias, failure and outcome were noted. Results: 96% of diabetic patients were found to be having CRP level >7mg/l as compared to 80% of non-diabetic patients with acute myocardial infarction. The mean CRP in diabetic group was 51.80 mg/l as compared to 15.78mg/l in non-diabetic group which was statistically significant (p<0.001).10% of diabetic patients had mortality as compared with 4% in non-diabetic group. Diabetic patients who died in hospital presented with higher plasma levels of CRP on admission as compared to non-diabetic patients. Conclusions: CRP on admission is a strong predictor for hospital morbidity and mortality in both diabetic and non-diabetic patients with acute myocardial infarction. Diabetic patients presented with higher CRP levels compared with those in non-diabetic patients with acute myocardial infarction. CRP may serve as marker in predicting the hospital mortality in patients with acute myocardial infarction. It can be concluded that significant high values of CRP in diabetics may indicate a considerable damage to the vascular endothelium, which could play role in causation of cardiovascular events.